Traumatic brain injury (TBI) is among the leading causes of death and disability and the main cause of death among the under-45s.
Most patients with moderate to severe TBI are admitted to intensive care units (ICUs).
The “PROSAFE” ICU network was recently established in 5 European countries (Cyprus, Hungary, Italy, Poland and Slovenia), through EU funding (PHEA 2007331), and has continued to collect high-quality data beyond the grant duration.
In 2011, 225 ICUs had joined PROSAFE, recruiting a total of 73,163 patients, 2,694 of whom were admitted for TBI. Hence the network expects to enrol 7-9,000 moderate to severe TBI patients over 4 years.
Through the newly established CREACTIVE project, the PROSAFE consortium focuses attention on TBI, on which data collection started in March 2014.
The aims of the project are to consolidate the existing network in order to better describe the epidemiology of moderate-severe TBI in 7 countries (Greece and Israel have now joined the consortium); build a prognostic model based on short- and long-term outcome measures; identify the most effective clinical interventions for optimally treating TBI patients, and recognize the determinants of optimal vs suboptimal performance.
All TBI-CDEs endorsed by InTBIR will be collected, along with other items needed to develop a sensitive prognostic model, permitting the consortium to join forces with international collaborative initiatives in the field.
A dedicated repository will be set up for the collection of biological materials to identify prognostic markers and underlying genetic factors influencing response to treatment and final outcome.
A clinical imaging repository will also be implemented to collect anonymized clinical imaging data in order to evaluate variability in the progression of both the haemorrhagic lesion and the perilesional oedema and to assess their association with the outcome.
This places the PROSAFE consortium in a position to guarantee superior quality data collection in 7 countries and ensure its continuation beyond the life of the project.
These conditions are essential if the consortium is to contribute to Europe playing a key role in the success of the ongoing InTBIR initiative.